A new set of analyses of the NIMH-funded Treatment for Adolescents with Depression Study (TADS) were conducted to better understand what may predict the development of suicidal events during treatment. The analyses, which were published in the May 2009 issue of the Journal of Clinical Psychiatry, showed that youths with suicidal thoughts and more severe depression prior to treatment were at higher risk for suicidal events while undergoing treatment.

Source: Press Release, National Institute of Mental Health

A combination of psychotherapy and antidepressant medication appears to be the most effective treatment for adolescents with major depressive disorder-more than medication alone or psychotherapy alone, according to results from a major clinical trial funded by the National Institutes of Health's National Institute of Mental Health (NIMH). The study was published in the October 2007 issue of the Archives of General Psychiatry.

The long-term results of the Treatment for Adolescents with Depression Study (TADS) found that when adolescents received fluoxetine (Prozac) alone or in combination with cognitive behavioral therapy (CBT) over the course of 36 weeks, they recovered faster than those who were receiving CBT alone.