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Article discusses the use of Lithium and Divalproex Sodium being effective treatment for some juveniles with bipolar disorders.  By Robert Findling, et al.

This randomized, double-blind, placebo-controlled study examined the efficacy and tolerability of quetiapine in combination with divalproex (DVP) for acute mania in adolescents with bipolar disorder. It was hypothesized that divalproex (DVP) in combination with quetiapine would be more effective than DVP alone for treating mania associated with adolescent bipolar disorder. Furthermore, it was hypothesized that quetiapine would be well tolerated. Study by Melissa del Bello, MD, et al.

by Kowatch, Robert A. M.D.; Suppes, Trisha M.D., Ph.D.; Carmody, Thomas J. Ph.D.; Bucci, John P. M.A.; Hume, Judith H. M.S.; Kromelis, Michelle R.PH.; Emslie, Graham J. M.D.; Weinberg, Warren A. M.D.; Rush, A. John M.D.

Journal of the American Academy of Child & Adolescent Psychiatry Copyright 2000 © American Academy of Child and Adolescent Psychiatry, Volume 39(6), June 2000, pp. 713-720

Objective: To develop effect sizes for 3 mood stabilizers-lithium, divalproex sodium, and carbamazepine-for the acute-phase treatment of bipolar I or II disorder, mixed or manic episode, in children and adolescents aged 8 to 18 years.
Method: Forty-two outpatients with a mean age of 11.4 years (20 with bipolar I disorder and 22 with bipolar II disorder) were randomly assigned to 6 weeks of open treatment with either lithium, divalproex sodium, or carbamazepine. The primary efficacy measures were the weekly Clinical Global Impression Improvement scores and the Young Mania Rating Scale (Y-MRS).